Intra-Articular Autologous Platelet-Rich Plasma Hip Injection May Result in Osteogenesis Depicted as an Increase in Femoral Neck Bone Density

Marwa A Ahmed ,André Panagos

doi:10.4236/ojrm.2014.32005

Abstract

Osteoporosis has become one of the most prevalent bone diseases in developed countries. As the world’s population ages, this complex skeletal disorder is predicted to become an even more widespread and serious health condition, posing greater societal economic burden. Current therapeutic agents are limited by clinically significant side effects. In this report, we present a case that suggests intra-articular platelet-rich plasma (PRP) injectate may improve bone mineral density (BMD). This observation raises a question with exciting implications—can PRP serve as a viable and relatively safe, targeted treatment option to improve bone density?

Highlights

Platelet-rich plasma (PRP) is a form of treatment that has shown an exciting promise with regard to optimal and long-lasting hard and soft tissue healing in various fields of medicine, including sports medicine, orthopedics, ENT, ophthalmology, dentistry and maxillofacial surgery
Platelets are a rich source of cytokines, interleukin 8 and growth factors including platelet-derived growth factor (PDGF), transforming growth factor (TGF), vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF)
We report a case of an osteopenic female who was incidentally found to have a 12.2% increase in femoral bone mineral density (BMD) for several months following an ipsilateral autologous platelet-rich plasma intra-articular hip injection

Summary

Introduction

Platelet-rich plasma (PRP) is a form of treatment that has shown an exciting promise with regard to optimal and long-lasting hard and soft tissue healing in various fields of medicine, including sports medicine, orthopedics, ENT, ophthalmology, dentistry and maxillofacial surgery. (2014) Intra-Articular Autologous Platelet-Rich Plasma Hip Injection May Result in Osteogenesis Depicted as an Increase in Femoral Neck Bone Density. Osteoporosis is a complex bone disease that has become one of the most prevalent skeletal disorders in developed countries. It is characterized by low bone mass and microarchitectural deterioration of the bones, reflecting a disruption in the bone remodeling process. The four major anti-resorptive agents used in clinics are estrogen, selective estrogen receptor modulators, bisphosphonates and calcitonin While these agents have proven to be effective, their long-term use is limited by serious side effects [4]. We report a case of an osteopenic female who was incidentally found to have a 12.2% increase in femoral BMD for several months following an ipsilateral autologous platelet-rich plasma intra-articular hip injection

Case Presentation

Findings

Discussion

Conclusion