Intra-arterial nitrogen mustard in the treatment of pelvic cancer.

Abstract

Article1 April 1958INTRA-ARTERIAL NITROGEN MUSTARD IN THE TREATMENT OF PELVIC CANCERIRWIN H. KRAKOFF, M.D., ROBERT D. SULLIVAN, M.D.IRWIN H. KRAKOFF, M.D.Search for more papers by this author, ROBERT D. SULLIVAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-4-839 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn advanced and nonresectable neoplastic disease certain chemical agents have been found to have some effect in slowing the growth or in producing temporary regression of the tumor tissue. Nearly all of the agents which are capable of producing such effects, when administered systemically, also have toxic effects on the bone marrow, liver or other organs. Host toxicity is the limiting factor in dosage, and prevents the use of sufficient amounts of drug to produce drastic effects on the tumor.Klopp et al.1-4reported that in patients with inoperable cancer in whom the principal manifestations of the disease were largely...Bibliography1. KloppBatemanBerryAlfordWinship CTJCNCT: Fractionated regional cancer chemotherapy, Cancer Research 10: 229, 1950. Google Scholar2. KloppAlfordBatemanBerryWinship CTTCJCGNT: Fractionated intra-arterial cancer chemotherapy with methyl bis amine hydrochloride: a preliminary report, Ann. Surg. 132: 811, 1950. CrossrefMedlineGoogle Scholar3. BatemanKloppCromer JCCTJK: Hematologic effects of regional nitrogen mustard therapy, Blood 6: 26, 1951. CrossrefMedlineGoogle Scholar4. CromerBatemanBerryKennellyKloppPlatt JKJCGNJMCTLI: Use of intra-arterial nitrogen mustard therapy in the treatment of cervical and vaginal cancer, Am. J. Obst. and Gynec. 63: 538, 1952. CrossrefMedlineGoogle Scholar5. BiermanShimkinByronMiller HRMBRLER: The effects of intra-arterial administration of nitrogen mustard. V. Congrès internationale du Cancer, 1950, Hermann, Paris, p. 186. Google Scholar6. BiermanByronKelly HRRLKH: Therapy of inoperable visceral and regional metastases by intra-arterial catheterization in man, Cancer Research 11: 236, 1951. Google Scholar7. BonnerThurmanHomburger CDAF: A critical study of regional intra-arterial nitrogen mustard therapy in cancer, Ann. Surg. 136: 912, 1952. CrossrefMedlineGoogle Scholar8. GradyKrantzBrown EGSPF: Treatment of cancer by intermittent injection of nitrogen mustard via cannulated arteries, Ann. Surg. 137: 366, 1953. CrossrefMedlineGoogle Scholar9. BoimanHolzaepfelBarnes REJHAC: Intra-arterial nitrogen mustard in advanced pelvic malignancies, Am. J. Obst. and Gynec. 72: 1319, 1956. CrossrefMedlineGoogle Scholar10. SullivanJonesSchnabelShorey RDRTGJM: The treatment of human cancer with intra-arterial nitrogen mustard (methyl bis (2-chloroethyl) amine hydrochloride) utilizing a simplified catheter technique, Cancer 6: 121, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication August 26, 1957.From the Division of Clinical Chemotherapy, Sloan-Kettering Institute for Cancer Research, the Chemotherapy Service of Memorial and James Ewing Hospitals, and the Department of Medicine, Cornell University Medical College.†These studies were supported by research grants C1889 and CY3215 from the National Cancer Institute of the National Institutes of Health, Public Health Service; institutional grants from the American Cancer Society, the Damon Runyon Memorial Fund for Cancer Research, the Lasker Foundation and the Black-Stevenson Foundation.‡Present address: Manhattan Veterans Administration Hospital, New York, N. Y.Requests for reprints should be addressed to Irwin H. Krakoff, M.D., Memorial Center for Cancer and Allied Diseases, 444 East Sixty-eighth Street, New York 21, N. Y. 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