Intra- and Peri-Operative Outcomes Comparing Radical Retropubic and Laparoscopic Radical Prostatectomy: Results from a Prospective, Randomised, Single-Surgeon Study

Abstract

ObjectivesTo prospectively compare intra- and peri-operative outcomes of open radical retropubic prostatectomy (RRP) and laparoscopic prostatectomy (LRP) by a single surgeon. Patients and methodsOne-hundred-twenty, consecutive, age-matched patients diagnosed with clinically localized prostate cancer were eligible for surgery. Sixty patients underwent RRP and 60, LRP. Intra- and peri-operative parameters, pathologic findings and early complications were recorded. A validated visual analogue scale was used to assess pain in the recovery room, 3h after the operation and on post-operative days 1, 2 and 3. A cystogram was performed on post-operative day 5. ResultsOperating time was significantly shorter in the RRP group versus the LRP group (mean±SD, 170±34. 2 vs 235±49.9min, p<0.001). Blood loss was significantly less in the LRP group versus the RRP group (mean±SD, 853.3±485 vs 257.3±177ml, p<0.001), but no patient in either group underwent early re-intervention for bleeding. The RRP group showed a trend for higher use of analgesia. A watertight anastomosis was shown at cystourethrography and the catheter removed in 86% and 66% of LRP and RRP patients, respectively. The overall percentage of post-operative complications and positive margins were comparable. ConclusionLaparoscopic prostatectomy is an attractive alternative to open prostatectomy, offering the advantages of reduced blood loss and safe early catheter removal. Furthermore, the laparoscopic procedure proved to be safe oncologically. Long-term follow-up is required to compare functional results in terms of continence and potency.