Intra-abdominal fat accumulation is an important predictor of metabolic syndrome in young adults.

Masakazu Kobayashi,Ikuko Sagara,Atsushi Takeoka,Sayaka Ogawa,Peter Bernick,Masaki Hayashida,Tetsuya Kawano,Susumu Shirabe,Jun Tayama,Norio Abiru

doi:10.1097/md.0000000000022202

Masakazu Kobayashi, Ikuko Sagara + Show 8 more

Open Access

https://doi.org/10.1097/md.0000000000022202

Copy DOI

Journal: Medicine	Publication Date: Sep 11, 2020
Citations: 7	License type: CC BY 4.0

Affiliation: Nagasaki University, Access, Waseda University

Abstract

Metabolic syndrome (MetS), mainly caused by intra-abdominal fat (IAF) accumulation, is an important risk factor for cardiovascular disease. The prevalence of MetS increases rapidly after the age of 40 years, and it is presumed that there is a substantial proportion of MetS in younger age groups. However, the association of IAF with MetS in adults aged 20 to 30 years has not been fully investigated.This study aimed to determine the prevalence of MetS and to verify whether IAF accumulation is associated with other MetS-related metabolic disorders including dyslipidemia, high blood pressure, and high blood glucose among the Japanese population in their 20s.In this cross-sectional study, IAF area (IAFA) and MetS-related metabolic parameters were evaluated in university students in their 20s (n = 1822, 21.5 ± 1.5 years). IAFA was measured using a non-invasive device, DUALSCAN, which can be readily measured through the dual impedance method. The participants were divided into four groups according to IAFA: 0–49.9, 50–74.9, 75–99.9, and ≥100 cm2.MetS was prevalent in 3.3% and 0.0% of the males and females, respectively, according to the Japanese criteria of MetS. The sex- and lifestyle-adjusted odds ratios (ORs) for the three metabolic component levels of Mets were elevated in the larger IAFA groups compared to the smallest IAFA group, according to the level of IAFA. The levels particularly increased in participants with abdominal obesity, defined by both, IAFA and waist circumference rather than by waist circumference alone.IAF accumulation was significantly associated with MetS-related metabolic disorders in young adults. An evaluation of IAFA may contribute to the early prediction of the risk of developing MetS in the future.

Highlights

Metabolic syndrome (MetS) was prevalent in 3.3% and 0.0% of the males and females, respectively, according to the Japanese criteria of MetS
In Japan, the clinical criteria for MetS required the presence of intra-abdominal fat (IAF) accumulation, and any 2 of the following three mild metabolic disorders: (1) dyslipidemia, Editor: Fabio Comim
We used the criteria proposed by the Japanese Committee for the Diagnostic Criteria of Metabolic Syndrome in 2005.[4,5] The clinical criteria for MetS requires the presence of IAF accumulation (WC of ≥ 85 cm and ≥ 90 cm in males and females, respectively, which corresponds to IAF accumulation of ≥ 100 cm2) and any 2 of the following three mild metabolic disorders: (1) dyslipidemia, (2) increased blood pressure (BP), and

Summary

Introduction

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The data that support the findings of this study are available from a third party, but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are available from the authors upon reasonable request and with permission of the third party. A Center for Health and Community Medicine, Nagasaki University, Nagasaki, b Faculty of Human Science, Waseda University, Saitama, c Student Accessibility Office, Nagasaki University, d Department of Endocrinology and Metabolism, Nagasaki University Graduate School of Biomedical Sciences, e Akiyama Hospital, Nagasaki Japan, f Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan

Objectives

Methods

Results

Conclusion