Intoxication of Cypermethrin on Binding Site of Human Oxyhaemoglobin

Abstract

Pesticide exposure can occur by several routes in the same individual due to multiple uses, and there is likely to be additive toxicity in human. Cypermethrin a synthetic pyrethroid can produce a variety of acute health conditions and also carries several ecological risks. Hemoglobin is the protein that transports oxygen in the blood. Any change in heamoglobin may direct or indirect effect the human body. In this work, we report computational prediction of binding of cypermethrin pesticides on human oxyhaemoglobin [using Molegro Virtual Docker (MVD)] and evaluating the computational prediction on binding of human oxyhaemoglobin with cypermethrin pesticide and evaluate the Mole Dock Score, RMSD, affinity, interacting residues of receptor human oxyhaemoglobin, number of H-bond interaction, docking score and intracting interaction of residues. The energy bound conformation with lower value of selected ligand shows hydrogen bonding and electrostatic interactions. The binding affinity of cypermethrin pesticides is found to be -35.7414 KJ/mol, and bind with two hydrogen bonds with tyrosine 35 and serine 133. Frequent alterations in the expression of amino acid due to pesticide interaction with oxyhemoglobin may lead to produce carcinogenic cells in human beings.