Abstract
Introduction: Henna, has been applied in eastern cultures for many years, as a hair dye and tattoo. Paraphenylenediamine (PPD) is a kind of aromatic amine added to henna. The formulation formed when PPD added known to be highly toxic. 
 Case report: Here, a 16-year-old female patient admitted to an emergency clinic with severe angioedema, rhabdomyolysis, and acute renal failure caused by PPD after henna ingestion for suicidal purposes, was presented. An emergency tracheotomy was performed to the patient because of severe respiratory distress, and the patient was followed up by connecting to the mechanical ventilator in intensive care.
 Conclusion: PPD poisoning is a life-threatening condition, and there is no specific antidote for PPD intoxication. Early intervention to the patient is essential because it is life-saving.
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