INTIMA-MEDIA THICKNESS OF CAROTID ARTERY IN PATIENTS WITH BEHÇET DISEASE

Abstract

SESSION TITLE: Chest Infections and Disorders of the Pleura Abstract PostersSESSION TYPE: Original Investigation PostersPRESENTED ON: 10/18/2022 01:30 pm - 02:30 pmPURPOSE: Behcet's disease (BD) is systemic vasculitis, which affects all types and sizes of vessels. Increased carotid intima-media thickness (IMT) is parameter associated with subclinical atherosclerosis.To evaluate the IMT of carotid artery in patients with BDMETHODS: The study includes 95 patient with BD 45 healthy controls matched for age and gender. IMT were assessed by using high-resolution B-mode ultrasonography. High-sensitivity C-reactive protein (Hs CRP) concentration in the serum samples were measured by immunonephelometric assay (BN-100 Analyzer; Dade Behring).RESULTS: The male-to-female ratio was 3,7:1, the mean age of pts was 29.7 (23-35) yrs, the mean age at the disease onset - 19,9 (14-25) yrs, the mean disease duration - 9,6 (4-15) yrs. Arterial hypertension, smoked, diabetes mellitus, lipid profile, mean IMT carotid artery, IMT > 0,5-0,89 mm, IMT - 0,9 - 1,2 mm, IMT > 1,2 mm (plaques) were similar in BD pts compared with controls. In pts thinning IMT and concentration of hs CRP were significantly higher compared with controls (IMT <0,5 mm - 31,6% vs. 6,6%, p<0,05), (hs CRP 2,42 +-21,0 vs. 0,3 +-0,63, p <0,05). IMT correlate with age of pts, concentration of total cholesterol, LDL and hs CRP but did not created with clinical manifestation and disease duration. Carotid atherosclerotic plaques were found in 5 pts with BD - mean age 40,0+-8,1, who had traditional cardiovascular risk factors (high body masse index, hypertension) and received long time therapy with glucocorticoids.CONCLUSIONS: The thickness IMT in BD pts was lower than what we expected. The thinning IMT may be one of the risk factors for aneurysm formation in pts with BD.CLINICAL IMPLICATIONS: The thinning IMT may be one of the risk factors for aneurysm formation in pts with BD.DISCLOSURES: No relevant relationships by Zemfira AlekberovaNo relevant relationships by Lidia AnanyevaNo relevant relationships by Regina Goloeva SESSION TITLE: Chest Infections and Disorders of the Pleura Abstract Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/18/2022 01:30 pm - 02:30 pm PURPOSE: Behcet's disease (BD) is systemic vasculitis, which affects all types and sizes of vessels. Increased carotid intima-media thickness (IMT) is parameter associated with subclinical atherosclerosis.To evaluate the IMT of carotid artery in patients with BD METHODS: The study includes 95 patient with BD 45 healthy controls matched for age and gender. IMT were assessed by using high-resolution B-mode ultrasonography. High-sensitivity C-reactive protein (Hs CRP) concentration in the serum samples were measured by immunonephelometric assay (BN-100 Analyzer; Dade Behring). RESULTS: The male-to-female ratio was 3,7:1, the mean age of pts was 29.7 (23-35) yrs, the mean age at the disease onset - 19,9 (14-25) yrs, the mean disease duration - 9,6 (4-15) yrs. Arterial hypertension, smoked, diabetes mellitus, lipid profile, mean IMT carotid artery, IMT > 0,5-0,89 mm, IMT - 0,9 - 1,2 mm, IMT > 1,2 mm (plaques) were similar in BD pts compared with controls. In pts thinning IMT and concentration of hs CRP were significantly higher compared with controls (IMT <0,5 mm - 31,6% vs. 6,6%, p<0,05), (hs CRP 2,42 +-21,0 vs. 0,3 +-0,63, p <0,05). IMT correlate with age of pts, concentration of total cholesterol, LDL and hs CRP but did not created with clinical manifestation and disease duration. Carotid atherosclerotic plaques were found in 5 pts with BD - mean age 40,0+-8,1, who had traditional cardiovascular risk factors (high body masse index, hypertension) and received long time therapy with glucocorticoids. CONCLUSIONS: The thickness IMT in BD pts was lower than what we expected. The thinning IMT may be one of the risk factors for aneurysm formation in pts with BD. CLINICAL IMPLICATIONS: The thinning IMT may be one of the risk factors for aneurysm formation in pts with BD. DISCLOSURES: No relevant relationships by Zemfira Alekberova No relevant relationships by Lidia Ananyeva No relevant relationships by Regina Goloeva