Abstract
Intrauterine growth restriction (IUGR) is a clinical condition in which foetus cannot develop its own growth potential...
Highlights
Intrauterine growth restriction (IUGR) is a clinical condition in which foetus cannot develop its own growth potential [1,2]
Patients and Methods: We reviewed clinical charts of preterm infants born between December 2010 and January 2015, selecting children above 4 years of age, born preterm (
intestinal permeability (IP) was significantly increased in patients compared to controls (0.0945±0.063 versus 0.0158±0.006, respectively, p0.003) in 100% of patients compared to 5% of healthy subjects
Summary
Intrauterine growth restriction (IUGR) is a clinical condition in which foetus cannot develop its own growth potential [1,2]. Determining the urinary excretion of disaccharides and monosaccharides and the ratio of their excretion is a valid method for the measurement of IP. Monosaccharides, such as mannitol (M), pass through the transcellular routes, reflecting the degree of absorption of small molecules. The aim of this study was to evaluate IP in preterm children with history of IUGR and persistent growth delay at pre-schooler age, following the hypothesis that an increased IP may stay behind a chronic malabsorption and growth retardation. Our pilot study has assessed IP in a cohort of preterm children with history of intrauterine growth restriction (IUGR) and persistent growth delay
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