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Abstract
Rationale: The role of microbiota-gut-brain axis has emerged in the regulation of eating behavior and in the pathophysiology of anorexia nervosa (AN). Particularly, a gut-derived dysregulation of immune response has been proposed leading to immunoglobulins (Ig) directed against appetite-regulating peptides but intestinal permeability has been poorly documented. We thus aimed to evaluate intestinal permeability, appetite-regulating peptides and their reactive Ig in severely malnourished women with AN.
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