Abstract
We studied the autopsy material obtained from 7 children who died in the neonatal period in order to evaluate the composition of lymphocytes of the intestinal mucosa against the background of morphological changes in the tissues of the gastrointestinal tract in newborns with sepsis. The main group consisted of 4 children with neonatal sepsis, the control group – of 3 newborns who died from other causes. The research material included the specimen of the small and large intestine.Results. Small intestine: it was found that there were less CD4 + lymphocytes in the small intestinal mucosa in the group of children who died from neonatal sepsis in 75% of cases than in the control group, but this difference was not statistically significant (p=0.1). There were no differences in the number of CD8 + and CD20 + cells in the studied groups. Large intestine: the number of CD4 + lymphocytes of the mucous membrane of the colon was greater in the main group of children than in the control group (p=0.03). An increase in the number of CD4 + cells was registered in 3 of 4 cases of neonatal sepsis. The number of CD8+ and CD20+ lymphocytes in the studied groups was the same (р>0.05).Conclusion. The increase in T-lymphocytes CD4+ in the mucous membrane of the large intestine is probably connected with the antigenic stimulation of opportunistic intestinal bacteria. We found no morphological signs of the suppression of the cells of adaptive immunity associated with the intestinal mucosa.
Highlights
We studied the autopsy material obtained from 7 children who died in the neonatal period in order to evaluate the composition of lymphocytes of the intestinal mucosa against the background of morphological changes in the tissues of the gastrointestinal tract in newborns with sepsis
The main group consisted of 4 children with neonatal sepsis, the control group – of 3 newborns who died from other causes
Small intestine: it was found that there were less CD4 + lymphocytes in the small intestinal mucosa in the group of children who died from neonatal sepsis in 75% of cases than in the control group, but this difference was not statistically significant (p=0.1)
Summary
С целью оценки состава лимфоцитов слизистой оболочки кишечника на фоне морфологических изменений тканей желудочно-кишечного тракта у новорожденных при сепсисе проведено исследование аутопсийного материала, полученного от 7 детей, умерших в неонатальном периоде. Тонкая кишка: установлено, что количество лимфоцитов CD4+ слизистой оболочки тонкой кишки в группе детей, умерших от неонатального сепсиса, в 75% случаев было меньше, чем в контроле, однако это различие не было статистически значимым (р=0,1). Толстая кишка: в основной группе детей количество лимфоцитов CD4+ слизистой оболочки толстой кишки было больше, чем в контроле (р=0,03). For citation: Khaertynov Kh.S., Anokhin V.A., Burganova G.R., Pevnev G.O., Mavlikeev M.O., Kiyasov A.P., Nizamutdinov E.Z., Lubin S.A., Satrutdinov M.A., Pchenitchnyi P.V. Intestinal mucosal lymphocytes in neonatal sepsis. Цель исследования: оценка количественного состава лимфоцитов слизистой оболочки кишечника на фоне морфологических изменений тканей пищеварительного тракта у новорожденных при сепсисе
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
