Abstract
The intestinal microvascular architecture of dogs and baboons was studied with a silicone-rubber injection technique before and after intravenous injection of a near lethal dose of Escherichia coli endotoxin. In the control animals, species differences included the presence of marginal arteries in the jejunal villi of dogs but not of monkeys. Villi of the latter species received oxygenated blood from; capillaries which arise from a capillary plexus surrounding the crypts. After endotoxemia, there is no change in the small intestinal microvascular architecture of the baboon. Under the same conditions, the dog exhibits four characteristic alterations: (1) shortening of the villi by approximately 50%; (2) coiling and shortening of the core vessels within the villi; (3) dilation and congestion of the subepithelial plexus; and (4) mucosal and submucosal hemorrhage. These species differences provide a morphological explanation for the known pathological and hemodynamic differences exhibited by the gut of dog and monkey during experimental shock.
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