Intestinal Microbiota as a Necessary Basis for Homeostasis, General Pathology, and Ageing, or Back to Elia Metchnikov

Abstract

The article is aimed to overview the field of microbiota and endotoxin science and their role in the interaction with innate immune system and pathogenesis of a variety of acute and chronic diseases. The methodology for studying the LPS biological role under clinical conditions created by Russian scientists is based on the ability of LPS blood level reducing tools to increase the patient treatment efficacy. The next findings have been created and formulated: 1. The LPS and stress factors’ involvement to the induction of inflammation, general adaptation syndrome and disseminated intravascular coagulation (DIC) condition which represent starting points for the development of multiple organ failure syndrome; 2. The LPS involvement to pathogenesis of broncho-obstructive syndrome, of chronic hepatitis C, AIDS and SARS-COV-2, of atherosclerosis and acute myocardial infarction, of alimentary obesity, septic shock, and/or type 1 diabetes, of autoimmune diseases, etc.; 3. The creation of interdisciplinary definitions of inflammation and sepsis, and introduction into scientific semantics new definitions such as "Systemic Endotoxinemia" (SE) as an obligate homeostasis factor and "Endotoxin Aggression" (EA) as a pre-disease and/or universal factor of disease pathogenesis. Furthermore, it was found that some bacterial preparation have ability to strengthen the intestinal barrier, which appeared to be one of the most significant achievements of current clinical microbiology. The EA prevention and/or endotoxin elimination would become a mandatory component of the treatment and preventive medicine, including delaying aging. The finding that "inflammation as a driving forces of aging" would be considered as one of the most outstanding clinical achievements of the century. It is declared that aging represents “burning of human organism in the flame of inflammation”. It is suggested that a specific anti-endotoxin therapy could be developed to combat the pathogenesis of chronic and acute diseases. There are several approaches to reduce the LPS level in human body for health maintaining. The First International Congress "Intestinal Microbiota: Homeostasis, Inflammation, and Aging" is planned to be held in Russian Federation (not far from City-of-Kazan), from 6-8 September 2024. It may become the first worldwide discussion of the questions and problems raised here in sense of LPS-centered medicine, as well as a generalization of ideas on the role of intestinal endotoxins and stress in adaptation processes and induction of inflammation, inflammaging, and aging