Abstract
Meta-analysis is a statistical process summarizing comparable data from a number of scientific papers. The use of meta-analysis in microbiology allows decision-making that has an impact on public health policy. It can happen that the primary researches come to different conclusions, although these are targeted with the same research question. It is, therefore, inevitable to have the means to systematically evaluate information and compare research results. Ulcerative colitis together with Crohn’s disease are among the two main inflammatory bowel diseases. This chronic disease of the gastrointestinal tract, with an as yet unclear etiology, is presented by an uncontrolled inflammatory immune response in genetically predisposed individuals to as yet undefined environmental factors in interaction with the intestinal microbiota itself. In patients with ulcerative colitis (UC), changes in the composition and relative abundance of microorganisms could be observed. Sulfate-reducing bacteria (SRB), which commonly occur in the large intestine as part of the commensal microbiota of animals and humans involved in the pathogenesis of the disease, have been shown to occur. SRB are anaerobic organisms affecting short-chain fatty acid metabolism. This work outlines the perspectives of the use of meta-analysis for UC and changes in the representation of intestinal organisms in these patients.
Highlights
Ulcerative colitis (UC) is one of the chronic inflammatory diseases of the gastrointestinal tract [1,2]
It is thought that a lack of energy for colonocytes could lead to the onset of this disease [41,52]
Complex researches usually lead to a large number of identified records, to a much smaller number of studies included in the systematic survey, and even fewer of these studies included in the meta-analysis
Summary
Ulcerative colitis (UC) is one of the chronic inflammatory diseases of the gastrointestinal tract [1,2]. Meta-analysis is a statistical process summarizing comparable data from a large number of scientific papers. Meta-analysis is a statistical process summarizing comparable data from athat largis used for the systematic evaluation the results of previous totechnique reach validthat coni number of scientific papers. It is aofquantitative and formal research statistical a statistical process summarizing comparable data from a large papers clusions [18,19,20]. Due to itthe increase in thedifficult number to of scientific and compare the results of studies [18] It is, to have thedifficult means to toidentify systematically assess information dealing.
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