Abstract
Identified significant changes in the intestinal microbiome in patients with inflammatory bowel disease (IBD), serve as the reason for therapeutic interventions in order to correct it. Faecal microbiota transplantation (TFM) is an effective treatment for recurrent or refractoryClostridium difficileinfections, including in patients with inflammatory bowel diseases receiving immunosuppressive and anticytokine therapy.The results of studying the effectiveness of TFM using a filtered aqueous suspension of donors feces in the correction of intestinal microbiocenosis in patients with recurrent Clostridial infection (RCT), ulcerative colitis (UC) and irritable bowel syndrome (IBS) are presented. 2 weeks after the introduction of the supernatant, a suspension of fecal microorganism microorganisms in patients evaluated the dynamics of the total content of microorganisms and individual representatives of the intestinal microflora. It was found that the supernatant of an aqueous suspension of donor feces containing microbial exometabolites and other biologically active compounds in the short term has the most pronounced effect on the restoration of normal intestinal microflora only in patients with clostridial infection.
Highlights
a suspension of fecal microorganism microorganisms in patients evaluated the dynamics of the total content of microorganisms
It was found that the supernatant of an aqueous suspension
Vermeire S, Joossens M, Verbeke K, et al Donor species richness determines faecal microbiota transplantation success in inflammatory bowel disease
Summary
Identified significant changes in the intestinal microbiome in patients with inflammatory bowel disease (IBD), serve as the reason for therapeutic interventions in order to correct it. В течении последних нескольких лет ТФМ была успешно использована при лечении рецидивирующей инфекции Clostridium difficile (РКИ), приведшей к изменению микробиоты кишечника результате антибактериальной терапии, нередко, нерациональной, приведшей к излечению более чем в 90% случаев [7]. Учитывая противоречивые данные, полученные в результате использования ТФМ при различных патология, нами была выполнена работа, цель которой заключалась в изучении состояния микробиома и клинико-лабораторных показателей у пациентов с ЯК, СРК, КИ до и после проведения трансплантации донорской фекальной микробиоты. Анализ микробиоты был проведен у 22 человек только до начала терапии; 17 пациентов с СРК, средний возраст 30±5,4 года. Интересные показатели относительно Blautia, так сравнимы между собой пациенты с СРК и ЯК, в то время как доноры и пациенты с ЯК имели более низкое содержание данных микроорганизмов, то есть отмечается снижение Ruminococcaceae. 1±1 a 2±2 b 0,5±0,5 a 38±17 b 24±13 a 1±1 a 0,4±0,5 a 0,2±0,2 a Таблица 7
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