Abstract
BackgroundIntestinal metaplasia of the bladder is an uncommon glandular proliferation. We examined a large series of intestinal metaplasia for the clinicopathological features and discuss the significance of this lesion.MethodsAll cases of intestinal metaplasia diagnosed in our institution between 1990 and 2014 were retrospectively reviewed. Patients with a history of urothelial carcinoma or concurrent adenocarcinoma were excluded. Patient characteristics, pathological features, and follow-up outcomes were obtained.ResultsWe identified 89 patients with intestinal metaplasia during this period. Sixty seven were men and 22 were women. Mean age at diagnosis was 57 years (range 23–81). Common presenting complaints included haematuria (73 cases), mucosuria (13 cases), and irritative voiding symptoms (seven cases). The majority of intestinal metaplasias located on or near the trigone (67 cases). Eighty-two patients underwent transurethral resection of their lesions. Partial cystectomy was performed in the remaining seven patients. The mean follow-up of 78 patients was 105 months (range 6–255). One case of bladder adenocarcinoma was indentified 6 months later. The initial histologic findings had revealed intestinal metaplasia with severe dysplasia. Four patients presented recurrence during the follow-up, and this occurred 9, 13, 17 and 24 months after the surgery.ConclusionsAlthough intestinal metaplasia can be treated effectively by transurethral resection in most cases, its potential malignancy need to be taken into consideration after the evidence of recurrences and its association with bladder adenocarcinoma. Therefore, it is necessary to perform close surveillance following the surgery, particularly in patients with dysplastic changes.
Highlights
Intestinal metaplasia of the bladder is an uncommon glandular proliferation
After reviewing 53 cases, Corica et al concluded that Intestinal metaplasia (IM) did not seem to be a risk factor for bladder cancer [10], and frequent and long-term follow up was not advocated if a concurrent diagnosis of malignancy was excluded [11]
Among 27,424 patients registered in our bladder tumor database, we identified 98 patients diagnosis with IM between 1990 and 2014, resulting in an incidence of 0.26 % in bladder tumor population
Summary
Intestinal metaplasia of the bladder is an uncommon glandular proliferation. We examined a large series of intestinal metaplasia for the clinicopathological features and discuss the significance of this lesion. After reviewing 53 cases, Corica et al concluded that IM did not seem to be a risk factor for bladder cancer [10], and frequent and long-term follow up was not advocated if a concurrent diagnosis of malignancy was excluded [11]. Such published results have brought conflicting information to the practicing urologist
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