Abstract
The purpose of our study was to investigate the number of mast cells, intraepithelial lymphocytes /IEL/ and other inflammatory cells in the intestine of 14 children with treated coeliac disease following a single challenge with gluten at 5 hours. We examined the neutrophil chemotactic activity of sera obtained at 0, 1, 3, 5 and 24 hours after challenge. There was no significant change in the number of IEL, but the biopsy specimen obtained at 5 hours showed marked increase in inflammatory cells of lamina propria and a significant decrease in the number of mast cells /87± 26 cells/mm2 mucosa in the controlls, 32,3± 10, 5 cells/mm2 after challenge/. The chemotactic activity of sera showed a significant inrease between 1-5 hours after challenge in 10 out of 14 patients. Serum neutrophil chemotactic activity was measured by a modified Boyden-chamber. These findings suggest that degranulation of mast cells may be involved in the pathogenesis of the CD.
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