Abstract
The metabolism and transport of (1-naphthyl-1- 14C) N-methylcarbamate by everted sacs of rat small intestine in pH 6.5 medium were remarkably different from those reported for a pH 7.4 medium. Active liberation of naphthol from the carbamate by the intestine was demonstrated, and the rate of hydrolysis was greater in cranial than in mid or caudal intestine. Water-soluble 14C-metabolites were also synthesized more rapidly in cranial than in mid or caudal intestine. The major 14C-metabolite cochromatographed with naphthyl glucuronide, previously found to be the major metabolite in pH 7.4 medium. Net mucosal-to-serosal transfer of 14C occurred throughout the intestine but was most rapid in the cranial section. The serosal: mucosal concentration gradient of the water-soluble 14C-metabolites was greatest in the caudal section.
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