Abstract
The lymphatic absorption of simple examples of secondary-alcohol long-chain fatty esters (isopropyl esters) was studied with thoracic-duct fistula rats, to which the esters were orally administered. The absorption was evaluated, firstly by comparison with that of oleic acid given in admixture with the isopropyl ester, and secondly as weight recovered per unit time in thoracic duct lymph. Only small quantities of unhydrolyzed esters are recovered in the lymph, which seems related to the small solubilization of apolar compounds in conjugated bile salt micelles. A larger proportion of their chains are found in lymph lipids, principally as triglycerides, which means that they are hydrolyzed in the intestine. This hydrolysis is less important than that of dietary ethyl esters and triglycerides. It is concluded that the secondary fatty ester-hydrolyzing enzymic activity of rat pancreatic juice, which was recently demonstrated in vitro by other authors, is significant in the living rat, and that it could explain at least a part of the loss of the glycerol moiety which is observed when rats are fed with triglycerides.
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