Abstract
Intestinal fibrosis in inflammatory bowel disease (IBD) is due to dysregulation of the wound healing process. MicroRNAs (miRNAs) are essential for the control of many physiological and pathological processes, and they act as critical regulators of gene expression at the post-transcriptional level. However, the role of miRNAs in epigenetic regulation of canonical pathways in intestinal fibrosis remains poorly understood. Here, I review the crosstalk between fibrotic signaling, particularly the transforming growth factor (TGF)-β pathway, and miRNAs, highlight potential novel therapeutic targets, and address the challenges of miRNA research.
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