Abstract
Isolated segments of jejunum from Amphiuma absorb HCO 3 − electrogenically by a process sensitive to acetazolamide. Using a tissue chamber of special design which permits isolation of villus or intervillus epithelium the transepithelial electrical potential ( ψ ms ) of each region was measured. The serosa-negative ψ ms generated by the villus epithelium was more negative than that of the intervillus and exhibited greater sensitivity to acetazolamide. Both regions were responsive to other agents which alter epithelial ion transport. The results indicate that intestinal HCO 3 − absorption is localized predominantly within cells lining the villus epithelium.
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