Abstract
Objective. Anti-tissue transglutaminase (anti-TG2) IgA autoantibodies are detectable in serum of the great majority of patients with untreated coeliac disease (CD). Many evidence suggest that they are primarily produced in the intestinal mucosa. The detection of IgA anti-TG2 intestinal deposits is proposed to be a specific and sensitive tool for the diagnosis of CD. The aim of this work is to investigate the presence of anti-TG2 IgA autoantibodies in the small intestine of patients with potential CD (subjects with presence in the serum of anti-endomysium antibodies (EMA) and/or high levels of anti-TG2, and a normal intestinal mucosa). The presence of intestinal anti-TG2 IgA has been related to the evolution to severe enteropathy.
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