Abstract
The protective effect of β-mercaptoethylamine (MEA) and/or restriction of superior mesenteric vessel blood flow (clamping) before irradiation of only the exteriorized ileum and jejunum of the rat has been expressed as the percentage of crypts surviving 4 days after X irradiation. Clamping was more radioprotective than MEA pretreatment, and the effect observed from combining the two protective procedures was greater than from either used singly. Differences in the protection conferred and the slopes of the crypt survival curves obtained suggest that the mechanisms by which clamping and MEA protect are not the same. However, since combining the two procedures results in less protection than might be predicted by adding the effects of each separately, it may be concluded that the modes of action of MEA and clamping are not totally independent of each other.
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