Abstract
Summary: An immunoassay for rat intestinal calcium-binding protein (CaBP) employing antibody raised in chickens using purified rat intestinal CaBP has been used to measure immunoreactive CaBP in the duodenum of suckling and weanling rats. A 5-fold increase in immunoreactivity, associated with a 2 ½-fold increase in calcium-binding activity occurred at weaning, a period during which duodenal mucosal mass increased 2-fold and supernatant protein concentration increased 1 ½-fold. Speculation: The ontogeny of calcium-binding protein in the duodenum of young rats parallels the maturation of cholecalciferol hydroxylases and represents maturation of the intestine as an end organ responsive to the vitamin D endocrine system.
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