Abstract
The 3-hr cumulative biliary appearance of a bile salt and three representative organic dyes was studied in rats anesthetized with sodium pentobarbital. The substances were administered in one of the following locations: a branch of the portal vein, a 20-cm isolated loop of proximal jejunum, or a similar loop of distal ileum. Average biliary recoveries of 10 mg cholate, bromsulfonphthalein, diiodotetrachlorofluorescein (rose bengal) or phenolsulfonphthalein (phenol red) introduced slowly into the portal circulation were 97, 97, 68, and 23%, respectively. The respective recoveries of 30-mg quantities of these four substances placed in the intestinal loops were 43, 5, 2, and 1% proximally and 90, 5, 5, and 0.4% distally. These observations confirm the presence of a specific intestinal transport mechanism for cholate with maximal activity in the distal ileum. However, the three representative organic dyes are shown not to be carried by the intestinal bile salt transport mechanism and their movement from gut lumen to portal vein blood should be ascribed to a passive process.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
