Abstract

Patient-reported outcome (PRO) measures must provide evidence that their development followed a rigorous process for ensuring their content validity. To this end, the collection of data is performed through qualitative interviews that allow for the elicitation of in-depth spontaneous reports of the patients’ experiences with their condition and/or its treatment. This paper provides a review of qualitative research applied to PRO measure development. A clear definition of what is a qualitative research interview is given as well as information about the form and content of qualitative interviews required for developing PRO measures. Particular attention is paid to the description of interviewing approaches (e.g., semi-structured and in-depth interviews, individual vs. focus group interviews). Information about how to get prepared for a qualitative interview is provided with the description of how to develop discussion guides for exploratory or cognitive interviews. Interviewing patients to obtain knowledge regarding their illness experience requires interpersonal and communication skills to facilitate patients’ expression. Those skills are described in details, as well as the skills needed to facilitate focus groups and to interview children, adolescents and the elderly. Special attention is also given to quality assurance and interview training. The paper ends on ethical considerations since interviewing for the development of PROs is performed in a context of illness and vulnerability. Therefore, it is all the more important that, in addition to soliciting informed consent, respectful interactions be ensured throughout the interview process.

Highlights

  • Medical advances, increasing specialisation, rising patient expectations, and the complexity of health care have expanded the range of clinical research questions to address the patient’s experience of illness and treatment [1]

  • Patients’ perspectives on the symptoms they experience, how they feel and function, and their quality of life associated with their health condition and its treatment may be measured with patient-reported outcome (PRO)

  • Qualitative research has long made contributions in the health care field, in recent years, several researchers stressed the importance of this approach as the necessary starting point for developing measurement tools to be used in quantitative research in order to ensure content validity [8,9,10,11,12]

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Summary

Introduction

This requires the development of a discussion guide: a general plan of questions to ask, highlighting the specific important themes to address [8,9] This preparation allows for thinking through how to word open-ended questions and helps to avoid the formulation of loaded questions that bias responses [19]. Questions should be asked with tact and distinction with respect for the individual’s vulnerability This is true considering that interviews performed to develop PRO measures are performed with individuals confronted with a disease or with whom specific sensitive topics may be raised (e.g., psychological troubles, sexual life). These exceptions should be stated with the patient consent and/or assent form

Conclusions
16. Smith JA
20. Britten N
26. Mathieson CM: Interviewing the Ill and the Healthy
29. Barbour RS
35. Hughes KA: Comparing Pretesting Methods
43. Robertson R
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