Abstract
Interventions for maintenance of surgically induced remission in Crohn's disease: a network meta-analysis.
Highlights
Description of the conditionCrohn’s disease is a chronic inflammatory disorder that can involve any part of the gastrointestinal tract
There is no cure for the disease, so management strategies are instead focused on induction and maintenance of remission, as well as supporting the many other symptoms that impact patients affected by the condition
Endoscopic recurrence of disease has been reported to be as high as 73% at one year post surgery (Rutgeerts 1990), and clinical relapse rates have been reported to range from 20 to 86% at five years post surgery ( Gklavas 2017; Rutgeerts 2002)
Summary
Description of the conditionCrohn’s disease is a chronic inflammatory disorder that can involve any part of the gastrointestinal tract. Endoscopic recurrence of disease has been reported to be as high as 73% at one year post surgery (Rutgeerts 1990), and clinical relapse rates have been reported to range from 20 to 86% at five years post surgery ( Gklavas 2017; Rutgeerts 2002). Given these high relapse rates, there have been many studies to identify potential methods of prolonging postoperative remission, but there is no standard therapy for the prevention of postoperative recurrence in Crohn’s disease (Hanuaer 2001; NICE 2016). A number of agents have been studied, but considerable uncertainty remains as to the efficacy of such treatments
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