Abstract
Interventional techniques to manage cancer-related pain may be efficient treatment modalities in patients unresponsive or unable to tolerate systemic opioids. However, indication and selection of the right technique demand knowledge, which is still incipient among clinicians. The present article summarizes the current evidence regarding the five most essential groups of interventional techniques to treat cancer-related pain: Neuraxial analgesia, minimally invasive procedures for vertebral pain, sympathetic blocks for abdominal cancer pain, peripheral nerve blocks, and percutaneous cordotomy. Furthermore, indication, mechanism, drug agents, contraindications, and complications of the main techniques of each group are discussed.
Highlights
Nociception is the process by which information about actual or potential tissue damage is conveyed through the spinothalamic tract to the brain, where the information is processed and interpreted, and the descending pain modulatory system is activated [1]
These patients may alternatively benefit from interventional techniques such as neuraxial analgesia, minimally invasive procedures for vertebral pain, sympathetic blocks for abdominal cancer pain, Cancers 2019, 11, 443; doi:10.3390/cancers11040443
Percutaneous vertebroplasty (PV), kyphoplasty (KP), radiofrequency ablation (RFA), and cryoablation (CA) are minimally invasive procedures indicated for the relief of vertebral bone pain in patients with metastatic lesions and/or compression fracture without neurologic sequelae
Summary
Nociception is the process by which information about actual or potential tissue damage is conveyed through the spinothalamic tract to the brain, where the information is processed and interpreted, and the descending pain modulatory system is activated [1]. The interruption of nociceptive pathways at peripheral and central levels can be an alternative treatment approach for patients with cancer-related pain It can be done by interventional nondestructive or neuroablatory techniques and is indicated for the management of cancer-related pain with an unsatisfactory response to strong systemic opioids and adjuvant analgesics and/or in patients with intolerable side effects of systemic analgesics [2]. 2–5% of patients with advanced cancer have inadequate control of pain with systemic analgesics [4] These patients may alternatively benefit from interventional techniques such as neuraxial analgesia, minimally invasive procedures for vertebral pain, sympathetic blocks for abdominal cancer pain, Cancers 2019, 11, 443; doi:10.3390/cancers11040443 www.mdpi.com/journal/cancers. Knowledge regarding the five most essential classes of interventional techniques to treat cancer-related pain: Neuraxial analgesia, minimally invasive procedures for vertebral pain, sympathetic blocks for abdominal cancer pain, peripheral nerve blocks, and percutaneous cordotomy. We will briefly review indications, mechanisms, drug agents, current evidence, contraindications, and complications
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
