Abstract
Introduction: Global longitudinal strain (GLS) by two-dimensional speckle tracking echocardiography (2D STE) is useful for detection of subclinical left ventricular dysfunction with incremental prognostic value over left ventricular ejection fraction. Interval GLS assessment is recommended to monitor for cardiotoxicity (>15% relative percentage reduction from baseline is considered significant). Intervendor variability remains a dilemma such that an interval change in GLS across different vendors may be difficult to rationalise as a true effect or hardware-/software-related variation.
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