Abstract
There is currently limited evidence available regarding ideal timing for frozen embryo transfer (FET). Demonstrating that delaying FETs has fewclinicalbenefits would allow patients to proceed with FET at their earliestconvenience. To examine whether the time interval between stimulation cycle and subsequent FET affects pregnancy and live birth rates. This retrospective cohort study, based in a multi-site private in vitro fertilisation (IVF) clinic categorised women into two groups: those having FET cycles administered within 25-35days or 50-70days of IVF stimulation cycle and embryo freeze. Outcomes measured were clinical pregnancy and live birth rates. When comparing the patients who have had a 25-35days gap between embryo freeze and FET, to the matched patients who had a 50-70days gap, the statistically significant results showed an adjusted odds ratio for live birth of 1.31 (1.02-1.67). The adjusted odds ratio for clinical pregnancy in matched case:control analysis was not statistically significant at 1.22 (0.97-1.53). A gap of 25-35days between embryo freeze and FET was associated with improved live birth rates compared to a gap of 50-70days.
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