Intertraffic of Endothelin 1 and Thrombospondin 1 between lungs and myocard via pulmonary circulation can alter cardiac loads, tissue integrity and atrial blood coagulability

Sven Kurbel

doi:10.12688/f1000research.12408.1

Abstract

Similar expression patterns of mRNA profiles for Endothelin 1 (ET-1) and Thrombospondin 1 (TSP1) from GeneAtlas U133A, gcrma, suggest that these two mediators are dominantly synthesized in the myocard and lungs. This paper proposes that intertraffic of these two mediators between myocard and lungs via pulmonary and coronary vessels optimizes cardiopulmonary functions and maintains their tissue integrity. A controlled delivery of endocrine mediators to the left and to the right heart is done by the coronary sinus (CS) that drains venous blood to the right atrium, and Thebesian veins (TVs) that open in all four heart cavities. Myocard and pulmonary capillaries are connected as a bidirectional portal system. Mediators from lungs can directly influence myocardial cells after entering the coronary circulation, while mediators in the myocardial venous blood that drain into the right heart will initially affect lungs. Strain induced myocardial ET-1 secretion into the right heart and pulmonary circulation increases the right heart afterload by constricting pulmonary vasculature. The same action reduces the left heart preload. Pulmonary ET-1 secretion can protect lungs from overperfusion by increasing the left heart afterload through constriction of peripheral arterioles. Chronic tissue overexposure to ET-1 leads to pulmonary and myocardial fibrosis. TSP1 availability is important in tissues under mechanical stress, since TSP1 is an adhesive glycoprotein involved in cell-to-cell and cell-to-matrix interactions. Pulmonary and myocardial TSP1 secretion that enter the fibrillating left atrium can mimic actions of the platelet-derived TSP1 in promoting the thrombus formation.

Highlights

Unexpectedly similar expression patterns of mRNA profiles for Endothelin 1 (ET-1) and Thrombospondin 1 (TSP1) in GeneAtlas U133A1, suggest that these two mediators are dominantly synthesized in myocard and lungs
This paper proposes that endocrine intertraffic of these two mediators between myocard and lungs via pulmonary and coronary vessels might be important in optimizing cardiopulmonary function and maintaining tissue integrity of both organs
The proposed idea is that a controlled delivery to the left and to the right heart is done by the peculiar myocardial venous circulation that includes coronary sinus (CS) that drains venous blood to the right atrium, and Thebesian veins (TVs) that open in all four heart cavities[4,5], numerous at the ventricle apex and at papillary muscles base[6]

Summary

Introduction

The opening sentence again ‘suggests’ dominant synthesis in myocard and lungs. I suggest that amplification here of this logical sequence would be the best and easiest place to make this clearer. 3.) P 4 (of 8), right column, 3rd paragraph: The antecedent of ‘it’ in the first sentence (...endocrine loops it can be expected...) is not clear to me. Para: The intended meaning of the opening sentence (When considering...) is not clear. P. 5, last para: I do not understand what you mean by ‘repetitive’ in this opening sentence. P. 6, “Disorders possibly...” paragraph: Would ‘produced by’ be better than ‘of’ so sentence might read “Table 2. Are arguments sufficiently supported by evidence from the published literature? The benefits of publishing with F1000Research: Your article is published within days, with no editorial bias You can publish traditional articles, null/negative results, case reports, data notes and more The peer review process is transparent and collaborative Your article is indexed in PubMed after passing peer review Dedicated customer support at every stage

Wearn JT