Abstract
An intraspecific mouse somatic cell hybrid population (C3H X C57BL) and its clonally derived descendants were studied. The modal chromosome number of the cloned hybrid decreased by 12% after 86 tissue culture passages, and by 20% after 2 years of tumor passage. This moderate loss of chromosomes represented a genuine reduction and could not be attributed to the centric fusion of acrocentric chromosomes. Intraspecific isoenzyme genetic variants specific for and different between C3H and C57BL cells were retained in the hybrids. The enzyme variants could be employed to deduce the balance between the input parental genomes in the hybrids.
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