Abstract
CBA, CC57BR, C57B1/6, BALB/c, and outbred white mice were intraperitoneally or subcutaneously (C57B1/6 strain) immunized with sheep red cells in a dose optimal for the development of delayed-type hypersensitivity but subthreshold for antibody production. Seven days later the mice were reimmunized with sheep red cells in various doses subcutaneously (CBA, C57B1/6, BALB/c, outbred mice) or intraperitoneally (CBA, CC57BR, outbred mice), and 5 days after reimmunization the intensity of antibody production and delayed-type hypersensitivity was assessed. Intact mice were controls. The immunization was found to selectively enhance delayed-type hypersensitivity in C57B1/6, CC57BR, and BALB/c mice and to intensify antibody production in CBA mice; both phenomena were observed in outbred mice.
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