Abstract
Polymyositis (PM) and dermatomyositis (DM) are autoimmune diseases, the main manifestation of which is symmetric muscle weakness of the proximal limbs, associated with inflammation of the striated muscles. Some PM/DM patients have pulmonary involvement and positive antisynthetase antibodies (ASA). The presence of ASA in PM/DM characterizes the unique phenotype of antisynthesis syndrome (ASS), which has a high risk of developing interstitial lung disease (ILD). Diagnosis of ASS is very difficult due to the large variability of clinical signs, which may include myositis, ILD, arthritis, Raynaud's phenomenon, ‘mechanic’s’ hand, skin rash, fever. There are two clinical observations of ILD in PM and DM in this article, showing the dynamics of symptoms for several years and difficult diagnosis of these diseases.
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