Abstract
Background: Resistance against drug delivery is a challenge in oncology, preventing the development of optimal therapeutic outcomes. This has been related to a group of hostile biophysical characteristics in the tumor microenvironment. Among them, the elevated interstitial fluid pressure (IFP) in solid tumors has been identified as a barrier for drug transport. Also, the hydraulic conductivity (K) of tumor stroma strongly correlates with the IFP. However, values of K in human cancer tissues are quite limited.
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