Interspecies toxicity correlations of rat, mouse andPhotobacterium phosphoreum

Abstract

AbstractThis study investigates quantitatively the interspecies relationships of the acute toxicity of 684 organic chemicals to the rat, the mouse, and the luminescent marine bacteriumPhotobacterium phosphoreum, commonly known as the Microtox® test The results indicate significant relationships between the Microtox EC50 and rat and mouse LD50 values The goodness of fit increases strongly from the oral to the intraperitoneal to the intravenous route of administration for each of the mouse and rat Standard errors of the estimated rat values range from 0 52 to 0 72 log units of toxicity (after and before outlier removal, respectively) over a toxicity range of 4 6 (intraperitoneal) to 5 0 (oral) log units (mmol/kg body weight) of toxicity For each of the three routes of administration, rat and mouse data are also highly correlated This allows the computation of rat toxicities from mouse data and vice versa with standard errors of the estimates of 0 28 (intraperitoneal) to 0 30 (oral) log units