Interscan reproducibility of cardiovascular magnetic resonance myocardial perfusion reserve index in women with suspected coronary microvascular dysfunction and no obstructive coronary artery disease

Ahmed Albadri,Louise E Thomson,Manish Motwani,Daniel S Berman,Behzad Sharif,Debiao Li,Janet Wei,Michael D Nelson,C Noel Bairey Merz,Puja K Mehta,Galen Cook-Wiens,Sofy Landes

doi:10.1186/1532-429x-18-s1-p82

Abstract

Background Cardiovascular magnetic resonance (CMR) myocardial perfusion reserve index (MPRI) has recently shown promise for detecting coronary microvascular dysfunction (CMD) in women with signs and symptoms of ischemia and no obstructive coronary artery disease (CAD). Prior CMR studies in CAD populations and in healthy volunteers have shown good intra and interobserver reproducibility for MPRI. However, interscan reproducibility is more variable. If MPRI is to be considered useful for the detection of CMD in women, the interscan reproducibility in this population must also be understood, such that proposed MPRI cut-off thresholds can be appropriately adjusted. Therefore, the aim of this study was to determine the interscan reproducibility of MPRI in women with suspected CMD.

Highlights

Cardiovascular magnetic resonance (CMR) myocardial perfusion reserve index (MPRI) has recently shown promise for detecting coronary microvascular dysfunction (CMD) in women with signs and symptoms of ischemia and no obstructive coronary artery disease (CAD)
If MPRI is to be considered useful for the detection of CMD in women, the interscan reproducibility in this population must be understood, such that proposed MPRI cut-off thresholds can be appropriately adjusted
The aim of this study was to determine the interscan reproducibility of MPRI in women with suspected CMD

Summary

Introduction

Cardiovascular magnetic resonance (CMR) myocardial perfusion reserve index (MPRI) has recently shown promise for detecting coronary microvascular dysfunction (CMD) in women with signs and symptoms of ischemia and no obstructive coronary artery disease (CAD). Prior CMR studies in CAD populations and in healthy volunteers have shown good intra and interobserver reproducibility for MPRI. If MPRI is to be considered useful for the detection of CMD in women, the interscan reproducibility in this population must be understood, such that proposed MPRI cut-off thresholds can be appropriately adjusted.

Objectives

Methods

Results

Conclusion