Abstract

Eating, drinking, irritability, muricide, and copulation were measured in 31 male rats before and after coronal knife cuts in the septal region or a control operation; in addition, activity was measured postoperatively. Cuts restricted to the area immediately ventral to the septum at a level anterior to the anterior commissure resulted in hyperdipsia, and hypoactivity. Cuts located posterior to the anterior commissure and lateral to the fornix resulted in irritability and hyposexuality. Cuts involving the tracts of the stria terminalis and the internal capsule resulted in slight irritability and severe hyposexuality. No significant correlations between the various behavioral effects were found. It was concluded that the neural pathways mediating drinking, irritability, copulation, and activity are relatively distinct.

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