Abstract
1. In intact rats with a regular estrous cycle, in all stages of the cycle the circadian rhythm of secretion of gonadotropic and sex hormones is the same and is characterized by a maximum content of estradiol in the blood in the morning and of gonadotropins and progesterone in the evening. 2. In the normal ovulatory cycle, the circadian rhythms of secretion of the sex and gonadotropic hormones are transformed as a result of their mutual potentiation into preovulatory peaks, acquiring the ability to stimulate ovulation. 3. In female rats with an irregular estrous cycle, neonatally androgenized with small doses of testosterone, the circadian rhythm of secretion of gonadotropic and sex hormones is preserved. 4. The maintenance of a constantly elevated (at the level of the values in the proestrus stage in the normal state) secretion of estradiol in neonatally androgenized rats with an irregular cycle prevents the transformation of the circadian rhythm of secretion of gonadotropins into the preovulatory peak without supplementary stimulation.
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