Abstract
Background Hypertrophic cardiomyopathy (HCM) is characterised by left ventricular hypertrophy, myofibre disarray as well as interstitial and replacement fibrosis. These characteristics are likely the underlying cause of reduced ventricular compliance and cardiac arrhythmias which subsequently impact on quality of life and outcome. Cardiac magnetic resonance (CMR) based late gadolinium imaging (LGE) has emerged as a prognosticator in multiple cardiac myopathies, including HCM, and is able to demonstrate a type of myocardial scarring that has been likened to replacement fibrosis. CMR based T1 mapping techniques on the other hand are thought to be able to also detect a more diffuse increase in collagen volume fraction of myocardial tissue (i.e. diffuse fibrosis). It has been argued that the latter type of fibrosis may be reversible up to a certain stage. However, even in the physiologically unlikely scenario that both fibrotic processes were independent of each other above mentioned CMR based technologies are not.
Highlights
Hypertrophic cardiomyopathy (HCM) is characterised by left ventricular hypertrophy, myofibre disarray as well as interstitial and replacement fibrosis
Cardiac magnetic resonance (CMR) based late gadolinium imaging (LGE) has emerged as a prognosticator in multiple cardiac myopathies, including HCM, and is able to demonstrate a type of myocardial scarring that has been likened to replacement fibrosis
There was a significant correlation between LV mass (LVM) and MFF (r=0.67;p=0.001 using the FWHM and 2SD thresholds)
Summary
Hypertrophic cardiomyopathy (HCM) is characterised by left ventricular hypertrophy, myofibre disarray as well as interstitial and replacement fibrosis. These characteristics are likely the underlying cause of reduced ventricular compliance and cardiac arrhythmias which subsequently impact on quality of life and outcome. Cardiac magnetic resonance (CMR) based late gadolinium imaging (LGE) has emerged as a prognosticator in multiple cardiac myopathies, including HCM, and is able to demonstrate a type of myocardial scarring that has been likened to replacement fibrosis. Aims We sought to investigate the relationship between LV mass (LVM), LGE imaging, using multiple cut-off points for signal differences to normal myocardium, and T1 mapping in order to gain a better understanding of myocardial tissue characteristics (i.e scar volume/diffuse fibrosis) as well as the interconnection of LVM, LGE and T1 mapping as currently applied
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
