Abstract
Immunological reactions of catalase in the erythrocytes of normal, hypocatalasemic, and acatalasemic individuals were investigated using specific antisera prepared against purified human erythrocyte and hepatic catalases and against human C-reactive protein. Acatalasemic erythrocytes examined with anti-erythrocyte catalase antiserum were totally deficient in one of the three components which were regularly observed in normal erythrocytes, while hypocatalasemic erythrocytes revealed only a partial deficiency of this same component. Antihuman hepatic catalase antiserum failed to develop a visible precipitin reaction with lysates of acatalasemic erythrocytes while those of normal erythrocytes gave distinct precipitation in the agar medium. Immunologic reactions between erythrocyte catalase and C-reactive protein also were examined. The results of these studies suggest that molecular subunits of erythrocyte catalase and C-reactive protein are antigenically similar. The hypothetical implications of the above observations are discussed.
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