Interrelation of a gene polymorphism of vascular endothelial growth factor VEGF -634G/C
 (rs 2010963) with a functional condition of kidneys at patients with different phenotypes of an obesity.

Abstract

Objective. To study interrelation of a polymorphism genes VEGF- 634G/C with a functional condition of kidneys at patients with different phenotypes of an obesity. Materials and methods. The research included 170 people aged from 25 up to 55 years (90 patients with an obesity, metabolic disturbances and AG "the complicated obesity", 50 - with an obesity without metabolic disturbances "metabolic healthy obesity", 30 people with AG without an obesity), 50 healthy respondents without obesity. Clinical-biochemical indicators, the VEGF level in blood and urine, MAU, collagen IV, a polymorphism of a gene VEGF -634G/C were investigated. Results. In the CO group it is established higher VEGF levels in a blood and urine, MAU, collagen IV In the CO and AG groups without an obesity there was a prevalence minor an allele C (р =0,028; QR=1,89) and (р=0,04; QR=1,83) unlike control. The adverse homozygote CC met in a group ofpersons with high MAU (%=6,9; р=0,01). The association polymorphism of a gene VEGF - 634G/C with the SBP (р=0,014), GFR (р=0,014), MAU (р=0,031), collagen IV (р =0,032), and with high levels VEGF (р <0,001) was established. Conclusions. Distribution of genotypes of the region genes of VEGF- 634G/C taped association of a carriage allele C with AG and the complicated obesity. In groups of patients with an obesity MAU level was associated with a homozygote CC. In groups with obesity and AG of the VEGF level in urine becomes perceptible, at conservation of the MAU and GFR normal values.