Interrelation between the main immunoglobulin isotypes in sheep

Abstract

Blood and nasal secretion samples were taken once in the middle of the month for 10 months from sheep and for 6 months from lambs. The level of immunoglobulins was determined by the simple radial immunodiffusion method. It was established that the relation between quantitative indices of Ig isotypes G, M, and A in clinically healthy animals, including during lactation, is constitutional and is expressed by a positive value of the correlation coefficient. A stable interrelation between immunoglobulins G and M of all investigated animal groups was established on the basis of correlation analysis of the level of the main immunoglobulin isotypes in clinically healthy animals. This index can serve as a diagnostic criterion for assessing an animal’s health and quality of immunoprophylaxis since a change in the direction of correlation between IgM antibodies of primary and IgG antibodies of secondary immunogenesis is a sign of disturbance of the organism’s immunoreactivity.