Interrelation Between Secretion and Incretion.

Abstract

All attempts of different investigators to find out the interrelation between the external and internal secretion of the pancreatic gland have not been successful because the methods used, evaluation of blood sugar in the peripheral blood,1, 2, 3 or acute pancreatico jugular transfusion experiments on anesthetized dogs4 lack the conclusiveness of direct physiological research under natural conditions.We used angiostomized dogs with pancreaticoduodenal and ad-renolumbal canulas. We know the secretion curves of pancreatic juice of the dog after feeding with proteins, carbohydrates and fats.5 We built up curves of insulin and adrenalin incretion during digestion of the same species of food.Comparison of the curves of external and internal pancreatic secretion shows no parallelism.After feeding with cream, which is usually followed by abundant secretion of pancreatic juice, no insulin incretion at all could be detected. After feeding with meat, after which, during the first hours, a rapid rise of external pan...