Interrelation between Recurrent Pregnancy Loss and Antiphospholipid: A Clinico-Diagnostic Perspective

Abstract

Recurrent pregnancy loss, one of the crucial reproductive health concerns affecting 6% of couples. Clinically recognized pregnancy loss is familiar, occurring in approximately 15–25% cases of pregnancy. The most common cause of recurrent pregnancy loss is cytogenetic anomaly, antiphospholipid antibody, metabolic and hormonal disorders. However, approximately 50% cases of recurrent pregnancy loss remain unexplored. Recurrent pregnancy loss is correlated with specificity of antiphospholipid like anti-β2-glycoprotein-I antibodies, lupus anticoagulant, anti-cardiolipin antibodies, and anti-phosphatidylserine. aPL inhibits the release of human chorionic gonadotropin (HCG) hormone from placenta, trophoblast growth, migration, and cell adhesion while induce the inflammatory response in earlier pregnancy. Some clinical studies reported that occurrence of antiphospholipid during recurrent pregnancy loss is uncommon. In this time line article, we are focusing on the role of antiphospholipid in the recurrent pregnancy loss and clinico-diagnostic against recurrent pregnancy loss.