Abstract
Data are presented for the interactions of β-cyclodextrin and sodium deoxycholate with 11 pharmaceutical agents in aqueous solution. Three of the compounds were also studied as to possible reactivity with deoxycholic acid. Interactions were observed with all of the systems studied. Similar solubility isotherms were obtained for the three pharmaceuticals when interacted with both deoxycholic acid and its sodium salt indicating possible similarities in the reaction mechanisms for these two complexing agents. The larger molecules showed a lower degree of interaction with both β-cyclodextrin and sodium deoxycholate, indicating the importance of molecular size and structure for optimum reactivity. Stoichiomet ries could he det ermined for several of the interactions due to the presence of plateau regions in their solubility isotherms. Formation constants and free energies of formation are also reported for a number of the insoluble complexes.
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