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Abstract
Periodontal disease is a chronic multifactorial inflammatory pathology influenced by biofilm dysbiosis and behavioral and systemic factors. The objective was to interpret the association between periodontal disease and stress using the PRISMA 2020 methodology. A systematic literature review was conducted in high-impact databases. Cross-sectional and case-control studies that related psychological disorders and periodontal disease using psychological scales and biomarkers were selected. The results indicated a significant relationship between stress and periodontitis, highlighting the role of cortisol and other inflammatory mediators. The evidence suggests that stress may influence the progression of periodontal disease by modulating the immune system and changes in health-related behaviors. It is concluded that an interdisciplinary approach in the treatment of periodontal disease is essential, integrating psychological and medical evaluation to improve oral health
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