Interpretation of Tailing Phenomenon of Survivor Curve and Inactivation of Virus by Plasma Exposure

Abstract

Volume 3 • Issue 8 • 1000181 Pharmaceut Anal Acta ISSN: 2153-2435 PAA, an open access journal There are two questions difficult to answer. One is the tailing phenomenon of survivor curve of plasma sterilization and the other is whether plasma clusterR can inactivate bacteria and virus. Tailing is the phenomenon illustrated in Figure 1 [1]. Many physics researcher interpreted it as being done by Moison [2], which several different kinetics may co-exist. The author deny their interpretation and considers it is due to clumping phenomenon of biological indicator (BI, Figure 2) [3] because penetration depth of gas plasma is less than 1 μm and the thickness of each bacterial spore of BI is around 1 μm. Therefore if clumped, the second layer of BI by plasma exposure will be protected with the first layer. First layer will be inactivated with first order equation as straight line of survivor curve (Figure 2), but the second or third layer delayed inactivation by protection of the first layer, so the survivor curve tailed and as a whole it is not straight line (Figure 1) [4].