Abstract
The plasma unconjugated bilirubin concentration (Br) is related to the bilirubin production rate (BRP) and hepatic bilirubin clearance (C Br ) in the following manner: Br = BRP ÷ C Br . The distribution for Br in the normal population was calculated from this relationship, using normal values of BRP and C Br measured with labeled bilirubin. The results indicate that any individual with a Br exceeding 1.0 mg/100 ml (99% level) should be suspected of having abnormal hepatic function or bilirubin overproduction or both. A Br greater than 3.5 mg/100 ml usually indicates abnormal hepatic function, regardless of the BRP. A change in Br means that either bilirubin production or hepatic function has been altered, even if Br remains within the normal range.
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