Abstract
Pre-eclampsia is a major cause of maternal and fetal mortality in pregnancy. The identification of genetic variants which predispose to pre-eclampsia demands large DNA collections from affected mothers and babies and controls, with reliable supporting phenotypic data. The InterPregGen study has assembled a consortium of researchers from Europe, Central Asia and South America with the aim of elucidating the genetic architecture of pre-eclampsia. The MoBa collection is playing a vital role in this collaborative venture, which has the potential to provide new insights into the causes of pre-eclampsia, and provide a rational basis for novel approaches to prevention and treatment.
Highlights
The InterPregGen consortium, a multinational collaboration between research groups from Europe, Central Asia and South America, is seeking to identify genetic factors which predispose to pre-eclampsia, a quest which has proved challenging to investigators from around the world for decades
The InterPregGen consortium was formed to address these deficiencies, aiming firstly to include a sufficiently large number of subjects with rigorously defined pre-eclampsia to provide adequate statistical power for association studies to detect genetic variants with small effect sizes; secondly, to use genome-wide association screening (GWAS) to scan both the maternal and fetal genomes for variants that predispose to pre-eclampsia
The identification of genetic factors which predispose to pre-eclampsia is a large undertaking, in which MoBa has a key role
Summary
The InterPregGen consortium, a multinational collaboration between research groups from Europe, Central Asia and South America, is seeking to identify genetic factors which predispose to pre-eclampsia, a quest which has proved challenging to investigators from around the world for decades. Genome-wide linkage studies of pre-eclampsia, analysing families with two or more affected women from Australasia, Iceland, Finland and Holland, have each identified loci which appear to show linkage with preeclampsia in their populations, but these results have not been independently replicated [14,15,16,17,18].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
