Abstract
Background and Aims : Sphingosine 1-phosphate (S1P), traveling in plasma mainly bound to high-density lipoproteins (HDL), fulfills several tasks in immune and cardiovascular systems by binding to its G protein-coupled receptors (S1P1-5). SR-BI, an HDL receptor, is widely expressed in different cell types, including endothelial cells and macrophages, and plays key roles in cholesterol homeostasis and lipoprotein metabolism. Recent evidence showed that HDL-bound S1P stimulates the transient interaction between SR-BI and S1PRs, activating S1PRs.
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